“Magic is just science that we don’t understand yet.”
-Arthur C. Clarke
We use the latest discovery methods in computational drug design and bioinformatics combined with predictive in vitro assays to determine most relevant bio-molecular targets and their fitting small-molecule inhibitor or agonist candidates. These tools have been essential in making right choices within huge amount of data generated by the molecular sciences, and to turn this the data into insightful guidelines for novel therapeutic compounds. Their eventual destiny is to turn into active principles of our forthcoming products.
Phases of Development
Determination of relevant molecular target (protein or oligonucleotide) or active compound having known interaction with target of choice. Verification of activity or target "druggability" via computational modeling, appropriate cell assays, next generation sequencing and proteomics.Stage 1
Selection of most promising natural compounds interacting with target of choice using in silico screening such as computational docking accompanied by cell assays.Stage 2
Examination of key bio-molecular interactions between lead compounds and target employing X-ray crystallography and computational drug design strategies such as docking and binding free energy calculations.Stage 3
Enhancement of compound properties such as permeability, selectivity or resistance to metabolic transformations. This stage embraces extensive use of computational design coupled with organic synthesis and cell assays.Stage 4
Verification of compound potency, selectivity, possible toxicity, pharmacokinetic and pharmacodynamic properties in animal models.Stage 5
Adoption of specific pharmaceutical excipients and active compound delivery systems to achieve best product performance.Stage 6
Use of biotechnological methods such as enzyme, plant or microorganism enhancements to secure cost-effective production of potent ingredients.Stage 7
What we discover changes who we become.
Product Design and Manufacturing
Once the lead compounds are identified, an optimization in term of synthesis or different formulation strategy is performed in order to improve substance activity. This is followed by production scale-up using available biotechnology – microbial or plant modification for maximal compound yield. Our partner companies help us tremendously to realize ideas into finished products quickly without compromising quality or potency.
Biology is the most powerful technology ever created. DNA is software, protein are hardware, cells are factories.