Science

“Magic is just science that we don’t understand yet.”
-Arthur C. Clarke

Research Methods

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We use the latest discovery methods in computational drug design and bioinformatics combined with predictive in vitro assays to determine most relevant bio-molecular targets and their fitting small-molecule inhibitor or agonist candidates. These tools have been essential in making right choices within huge amount of data generated by the molecular sciences, and to turn this the data into insightful guidelines for novel therapeutic compounds. Their eventual destiny is to turn into active principles of our forthcoming products. 

In Vitro Assays

We're constantly developing advanced in vitro models and methods that increase predictive power for our future products safety and efficacy.

Phases of Development

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Target identification

Determination of relevant molecular target (protein or oligonucleotide) or active compound having known interaction with target of choice. Verification of activity or target "druggability" via computational modeling, appropriate cell assays, next generation sequencing and proteomics.

Stage 1
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Compound selection

Selection of most promising natural compounds interacting with target of choice using in silico screening such as computational docking accompanied by cell assays.

Stage 2
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Lead validation

Examination of key bio-molecular interactions between lead compounds and target employing X-ray crystallography and computational drug design strategies such as docking and binding free energy calculations.

Stage 3
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Lead optimization

Enhancement of compound properties such as permeability, selectivity or resistance to metabolic transformations. This stage embraces extensive use of computational design coupled with organic synthesis and cell assays.

Stage 4
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In vivo assessments

Verification of compound potency, selectivity, possible toxicity, pharmacokinetic and pharmacodynamic properties in animal models.

Stage 5
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Product formulation

Adoption of specific pharmaceutical excipients and active compound delivery systems to achieve best product performance.

Stage 6
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Compound production

Use of biotechnological methods such as enzyme, plant or microorganism enhancements to secure cost-effective production of potent ingredients.

Stage 7

What we discover changes who we become.

Product Design and Manufacturing

Once the lead compounds are identified, an optimization in term of synthesis or different formulation strategy is performed in order to improve substance activity. This is followed by production scale-up using available biotechnology – microbial or plant modification for maximal compound yield. Our partner companies help us tremendously to realize ideas into finished products quickly without compromising quality or potency.

Biotechnology

Using the latest accomplishments in biotechnology area, we aim to provide the highest quality ingredients that will be accessible to everyone.

Biology is the most powerful technology ever created. DNA is software, protein are hardware, cells are factories. 
-Arvind Gupta

Biosens

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